NIPAH VIRUS INFECTION (NiV)
NIPAH VIRUS INFECTION (NiV)
Why in News?
Recently, Scientists detected the presence of IgG antibodies against Nipah virus infection (NiV) in 51 bats that were captured from Karnataka, Kerala, Tamil Nadu and Puducherry.
- It is a zoonotic virus (it is transmitted from animals to humans).
- The organism which causes Nipah Virus encephalitis is an RNA or Ribonucleic acid virus of the family Paramyxoviridae, genus Henipavirus, and is closely related to Hendra virus.
- Hendra virus (HeV) infection is a rare emerging zoonosis that causes severe and often fatal disease in both infected horses and humans.
- It first broke out in Malaysia and Singapore in 1998 and 1999.
- It first appeared in domestic pigs and has been found among several species of domestic animals including dogs, cats, goats, horses and sheep.
- The disease spreads through fruit bats or ‘flying foxes,’ of the genus Pteropus, who are natural reservoir hosts of the Nipah and Hendra viruses.
- The virus is present in bat urine and potentially, bat faeces, saliva, and birthing fluids.
- The human infection presents as an encephalitic syndrome marked by fever, headache, drowsiness, disorientation, mental confusion, coma, and potentially death.
- Currently, there are no vaccines for both humans and animals. Intensive supportive care is given to humans infected by Nipah virus.
- Antibody, also called immunoglobulin, is a protective protein produced by the immune system in response to the presence of a foreign substance, called an antigen.
- A wide range of substances are regarded by the body as antigens, including disease-causing organisms and toxic materials.
- Antibodies recognize and attack onto antigens in order to remove them from the body.
Types of Antibodies
IgG - It is the main antibody in blood and it has a powerful ability to bind to bacteria and toxins, and thus it takes on an important role in the biological defense system.It is the only isotype that can pass through the placenta, and IgG transferred from the mother's body protects a newborn.
IgM - It is constructed of five units of basic Y-shaped structures and is mainly distributed to the blood. Produced first upon pathogen invasion by B cells, IgM has a key role in the initial immune system defense for protecting the body.The B-cell, also called B-lymphocyte, is a type of white blood cell that plays a significant role in protecting your body from infection.
IgA - While in blood, IgA is mainly present as monomers (the shape of a single Y), but it forms dimers (a combination of 2 Ys) in secretions such as bowel fluid, nasal discharge, and saliva, to prevent bacterial invasion from a mucous membrane. It is also present in breast milk and protects the gastrointestinal tract of newborns from bacterial and viral infection.
IgD - It is present on the surface of B cells and it is reported to play a role in the induction of antibody production and the prevention of respiratory tract infections.
IgE - It is believed that IgE was originally related to immunity reactions to parasites. By binding to mast cells, IgE is believed to be involved in allergies such as pollinosis.
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